Funded Projects

Last 5 years

Research Projects

Comparison of esketamine nasal spray versus aripiprazole, both in combination with a SSRI/
SNRI, in treatment-resistant major depressive disorder in elderly patients (CESAR) 

Call / Funding body: Independent Clinical Research Projects 2021 / Carlos III Health  Institute Grant ID:  ICI23_00029. Awarded budget: 1.085.289,50€. PI: Benedicto Crespo Facorro. Research team: Miguel Ruiz Veguilla, María Alemany Navarro, Nathalia Garrido Torres, Cándido García Sánchez, Idalino Rocha González, Bianca Sánchez Barbero, Eduardo García Ramos. Num of researchers: 27. Start/End dates: 01/01/2024 – 31/12/2027

Modular Mental Health Toolbox (MentBox)

Call / Funding body:  EU4Health Programme (EU4H-2023-PJ) / European Commission. Grant Agreement: 101161222. Awarded budget: 589.984 €. PI and affiliation: Ulrich Hegerl, European Alliance Against Depression. Research team: Benedicto Crespo Facorro, Miguel Ruiz Veguilla, Manuel Canal Rivero, Nathalia Garrido Torres, Idalino Rocha Gonzalez, Antonia Naharro Hernández, Juliana Rosa Muñoz. Num of researchers: 24. Start/End dates: 01/12/2024 – 30/11/2027

The Medical Technology Innovation Platform (ITEMAS-ISCIII)

Call / Funding body: Strategic Action in Health 2021-2023 / Institute of Health Carlos III. Grant ID PT23/00130. Awarded budget: 317.840€. PI: José Cañón Campos. Beneficiary Institution: Seville Biomedical Research Institute (IBIS). Innovation team: Idalino Rocha González. Nº of innovators: 26. Start/End dates: 01/01/2024 – 31/12/2026

Dysfunction of the Blood-Brain Barrier in schizophrenia: molecular underpinnings of
vulnerability or resilience (B3Phrenia)

Call / Funding body: Call for Joint Transnational Research Projects 2023 / ERA-NET NEURON. International Collaboration Research Projects 2023 / Carlos III Health Institute. Grant ID: AC23_2/00034. Awarded budget: 260.00€. PI: Benedicto Crespo Facorro. Research team: María Irene Ayuso Fernández (co-PI). Num of researchers: 9. Start/end dates: 01/01/2024 – 31/12/2026

Multidisciplinary CIBER study to optimize the treatment of schizophrenia by utilizing multi-omics data and biology of systems (SchizOMICS)

Call / Funding body: Independent Clinical Research Projects 2021 / Carlos III Health  Institute. Grant ID: ICI21_00089 Awarded Budget: 1.192.431 € PI: Javier Labad Arias (Consorcio Sanitario Maresme) Research Team: Benedicto Crespo Facorro, Francisco Gotor Díaz, Ana Sánchez Hidalgo, Miguel Ruiz Veguilla, Rubén Catalán Barragán, Idalino Rocha González, Manuel Canal Rivero, Nathalia Garrido Torres, Beatriz Oda Plasencia Nº of researchers: 71 Start/end dates: 01/01/2022 – 31/12/2026

Multisite Smartphone-based Ecological Momentary Intervention for suicide prevention 

Call / Funding body: Calls for Research and Innovation proposals / CaixaResearch Health call. Grant ID: . Awarded budget: 999.995€. PI: Enrique Baca-García, Fundación Jiménez Díaz, Madrid. Research team: Miguel Ruiz Veguilla. Num of researchers: 4. Start/end dates: 01/01/2024 – 31/12/2026

Menssana

Call / Funding body: Public Engagement Grants / Spanish Foundation for Science and Tecnology (FECYT). Grant ID: FCT-23-19391. Awarded budget: 40.000 €. PI: Benedicto Crespo Facorro. Team: Idalino Rocha González, Nathalia Garrido Torres, Ana Giménez Ciruela. Start/End Dates: 01/09/2024 – 30/08/2025

menteScopia

Call / Funding body: Public Engagement Grants / Spanish Foundation for Science and Tecnology (FECYT). Grant ID: FCT-23-18985. Awarded budget: 30.000 €. PI: Benedicto Crespo Facorro. Team: Idalino Rocha González, Rafaela de la Mata Hidalgo, Nathalia Garrido Torres, Ana Giménez Ciruela. Start/End Dates: 01/09/2024 – 30/06/2024

Decoding inflammasome signature-glia phenotype crosstalks during brain development: towards a mechanism-treatable model of schizophrenia

Call / Funding Agency: R&D&I projects in health/ Carlos III Health  Institute. Grant ID: PI22_01379. Awarded budget: 129.470 €. PI: Benedicto Crespo Facorro. Research team: Irene Ayuso Fernández, Ana Carmen Sanchez Hidalgo, Manuel Canal Rivero, Leonor Asensio Aguerri, Ruben Catalán Barragán. Num of researchers: 7. Start/End dates: 01/01/2023 – 31/12/2025

Risk of neurodevelopmental disorders in offspring of mothers infected with SARSCoV-2 during pregnancy: evidence from the SIGNATURE cohort

Call / Funding Agency: R&D&I projects in health/ Carlos III Health  Institute. Grant ID: PI22-0678 Awarded budget: 81.070 € PI: Miguel Ruiz Veguilla Research team: Manuel Canal Rivero, Álvaro López Díaz, Susana García Cerro, Ezequiel Ruiz-Mateo, Alberto Pérez Gómez N. of researchers: 7 Start/End dates: 01/01/2023 – 31/12/2025

Towards a molecular-based treatment of schizophrenia: the role of inflammasome and vascular alterations

Call / Funding body: Projects in Biomedicine and Health Sciences – FEDER funds 2022 / Regional Government of Andalusia Grant ID: PI-0014-2022 Awarded budget: 109.917€ PI: Benedicto Crespo Facorro, María Irene Ayuso Fernández Research team: Ana Carmen Sanchez Hidalgo, Nathalia Garrido Torres, Victor Darío Ramos Herrero N. of researchers: 5 Start/End dates: 01/01/2023 – 31/12/2025

A digital health platform for the secondary prevention of suicidal behavior (PROSODIC)

Call / Funding body: Projects of excellence 2021 PAIDI, Regional Government of Andalusia Grant ID: PROYEXCEL_00658 Awarded budget: 152.904 € PI: Marisa Barrigón N. of researchers: 8 Research team: Marisa Barrigón, Arturo Moreno. Germán Escobar, Ana Belén Naranjo, Manuel Canal, Idalino Rocha, Iván Pulido, David Gómez Start/End dates: 01/01/2023 – 31/12/2025

Comprehensive study of genetic and molecular variation in a Spanish Autism Spectrum Disorders cohort and the design of algorithms to identify diagnostic and therapeutic biotypes. (The ESTEA cohort)

Call / Funding body: Personalized Precision Medicine Projects 2021 / Institute of Health Carlos III. Grant ID: PMP21/00051. Awarded budget: 3.014.905 €
PI: María José Parellada Redondo. Research team: Nathalia Garrido Torres, Miguel Ruiz Veguilla, Manuel Canal Rivero, Ismael Fernández Cuervo, Inés Domínguez Gómez, José Luis Benítez Ortega, Ana Rubio García, Leonor Asensio Aguerri. Start/End Dates: 01/01/2022 – 31/12/2025

FARMacogenetics Applied to Predict the Response to treatment of the First Psychotic Episode (FARMAPRED-PEP)

Call / Funding body: Personalized Precision Medicine Projects 2021 / Institute of Health Carlos III Grant ID: PMP21/00085 Awarded Budget: 1.334.190 € PI: Sergio Mas Herrero Research Team: Benedicto Crespo Facorro, Álvaro López Díaz, Beatriz Oda Plasencia García de Diego, Lucía Garrido Sánchez, Rubén Catalán Barragán, Arturo Moreno Cordón, Itziar Coca Mendoza, Francisco Gotor Sánchez-Luengo Nº of researchers: 63 Start/end dates: 01/01/2022 – 31/12/2025

From hipothesis to validation with data science: a case study of drug repurposing in schyzophrenia (SchizoRWD)

Call/ Funding body: Digital and ecological transition projects 2021 / Spanish Ministry for Science and Innovation Grant ID: TED2021-132346B-I00 Awarded budget: 375.125 € Co-PIs: Javier Dopazo Blazquez y Benedicto Crespo Facorro, Research team: Javier Pérez Florido, Miguel Ruiz Veguilla, Rafael Romero García, Carlos Loucera Muñecas, María Peña Chilet N. of researchers: 7 Start/End dates: 01/01/2023 – 31/12/2025

Methylation, stresss, and neuroinflammation in the development of pre-school kid temperament: evidence from pregnant women with COVID-19 and their newborns SIGNATURE cohort study

Call / Funding body: Research project grants 2022 / Alicia Koplowitz Foundation Awarded budget: 45.000 € PI: Miguel Ruiz Veguilla Research team: Susana García Cerro, Andrés Antonio Román Jarrín, Víctor Pereira Sánchez N. of researchers: 4 Start/End dates: 01/01/2023 – 31/12/2024

Pilot study to evaluate effectiveness of online Metacognitive Famitly Coaching (MCTf) in mothers with psychosis and their adolescent children

Call / Funding body: Research Projects in Health / Institute of Health Carlos III Grant ID: PI21/00012 Awarded Budget: 73.810 € PI: Susana Ochoa Güerre Research Team: Manuel Canal Rivero, Cristian Montes, Nathalia Garrido Torres, Leonor Asensio Aguerri Nº of researchers: 28 Start/end dates: 01/01/2022 – 31/12/2024

MenteScopia – connecting with the teenage brain

Call / Funding body: Public Engagement Grants / Spanish Foundation for Science and Tecnology (FECYT). Grant ID: FCT-22-17694. Awarded budget: 25.500 €. PI: Benedicto Crespo Facorro. Team: Idalino Rocha González, Nathalia Garrido Torres, Ana Giménez Ciruela, Susana García Cerro. Start/End Dates: 01/09/2023 – 30/06/2024

Adapting and Implementing EAAD´s Best Practice Model to Improve Depression Care and Prevent Suicidal Behavior in Europe (Ment-Best)

Call / Funding body:  Annual Work Programme 2020 of the 3rd EU Health Programme (HP-PJ-2020) / European Health and Digital Executive Agency (HaDEA) Grant ID: Grant Agreement 101018325 Awarded Budget: 1.978.101 € PI & affiliation: Spain Coordinator Víctor Pérez Sola, Hospital del Mar Medical Research Institute, Research Team: Benedicto Crespo Facorro Nº of researchers: 34 Start/end dates: 01/04/2021 – 01/04/2024

Suicide risk prevention in the COVID-19 post-pandemic era : Integrating personalized and biological clinical models

Call / Funding body: Postdoctoral fellowship for joining SSPA centers / Regional Government of Andalusia Grant ID: RH-0081-2020 Awarded Budget: 185.010 € PI: Benedicto Crespo Facorro Research Team: Manuel Canal Rivero Start/end dates: 01/01/2021 – 31/12/2023

Cohort of pregnant women with COVID-19 and their newborns: identification of clinical and biological markers associated with abnormal neurodevelopment in newborns (SIGNATURE)

Call / Funding body: Grants for the financing of R&D&I in Biomedicine and Health Sciences in Andalusia – FEDER funds 2020 / Regional Government of Andalusia Grant ID: PECOVID-0195-2020 Awarded Budget:108.240 € Co-PIs: Benedicto Crespo Facorro / Nathalia Garrido Torres Research Team: Luis Alameda Fernández, Manuel Canal Rivero, Beatriz de Felipe y Peter Olbrich, Lucas Cerrillos, Juan F. Lopez-Giménez, Susana García Cerro, Alberto Pérez Gómez, María Carmen Gasca Capote, Rafael Castillo Reina, Candela Sánchez Tomás, María Aparcero, Ángela Cejudo López, Gracia Rodríguez, Martín Puertas Albarracín Nº of researchers: 15 Start/end dates: 26/05/2021-26/05/2023

Adaptation and validation of the Brief Assessment of Cognition App (BAC App) and the Virtual Reality Assessment of Functional Capacity Tool (VRFCAT) for use in Spain.

Call / Funding body: Strategic Action in Health 2017-2020 / Institute of Health Carlos III Grant ID: PI20/00066 Awarded Budget: 87.120 € PI: Rosa Ayesa Arriola Research Team: Salvador Perona Garcelán (líder HUVR , Francisco Gotor Sánchez-Luengo, Beatriz Oda Plasencia Nº of researchers: 32 Start/end dates: 01/012021 – 31/12/2023

The role of ADAMTS2 in schizophrenia: New mechanistic insights into brain functioning and therapeutic perspectives based on mouse and cellular models

Call / Funding body: Grants for the realization of R&D&I Projects. Public Entities 2020 / Regional Government of Andalusia – PAIDI Grant ID: P20_00811 Awarded Budget 152.730 € PI: Benedicto Crespo Facorro Research Team: Miguel Ruiz Veguilla, Susana García Cerro, María Irene Ayuso Fernández, Álvaro Flores Martínez, Collaborators: Celia Martín Cuevas, Ana Carmen Sánchez Hidalgo Start/end date: 23/06/2020 – 31/12/2022

Clozapine for the treatment of psychosis in people with intellectual disability (CLOZAID)

Call / Funding body: Independent Clinical Research Projects 2019 / Institute of Health Carlos III Grant ID: ICI19_00026 Awarded Budget: 537.290€ PI: Benedicto Crespo Facorro Research Team: Miguel Ruiz Veguilla, Ana Rubio García, Manuel Canal Rivero, Nathalia Garrido Torres, Álvaro López Díaz, Idalino Rocha González, Bianca Sánchez Barbero, Elena Ballesteros Raya, Elena María Dura Pérez, Pilar Roldán Domínguez, Encarnación Mª Sánchez Lara Nº of researchers: 23 Start/end dates: 01/01/2020 – 31/12/2023

MenteScopia

Call / Funding body: Public Engagement Grants / Spanish Foundation for Science and Tecnology (FECYT) Grant ID:  FCT-21-17004 Awarded budget: 16.000 € PI: Benedicto Crespo Facorro Team: Idalino Rocha González, Nathalia Garrido Torres, Ana Rubio García, Susana García Cerro Start/End dates: 01/09/2022 – 30/06/2023

Mens Sana

Call / Funding body: Public Engagement Grants / Spanish Foundation for Science and Tecnology (FECYT) Grant ID: FCT-21-17416 Awarded budget: 40.000 € PI: Benedicto Crespo Facorro Team: Idalino Rocha González, Nathalia Garrido Torres, Ana Rubio García, Susana García Cerro Start/End dates: 01/09/2022 – 30/06/2023

Searching for cellular, molecular and neurophysiological evidence for the stratified treatment of schizophrenia

Call / Funding body: Strategic Action in Health 2019 / Institute of Health Carlos III Grant ID code: CD19/00183 Awarded Budget: 80.598 € PI: Benedicto Crespo Facorro Research Team: Susana García Cerro Start/end dates: 15/01/2020 – 14/01/2023

Automated calculation platform for dosimetric equivalences in drugs (eDOSE)

Call / Funding body: Support Grants for Innovative Business Associations 2021 / Ministry of industry, trade and tourism Grant ID code: AEI-010500-2021b-11 Awarded Budget: 297.756€ PI: Asociación Cluster Granada Plaza Tecnológica y biotecnológica Research Team: Benedicto Crespo Facorro, Idalino Rocha González, Bianca Sanchez Barbero, Pablo Reguera Pozuelo Nº of researchers: 18 Start/end dates: 16/11/2021 – 21/08/2022

Connecting Worlds: Neuroscience for Adolescents (menteScopia)

Call / Funding body: Grants for the promotion of scientific, technological and innovation culture / Spanish Foundation for Science and Tecnology (FECYT) Grant ID code: FCT-20-16227 Awarded Budget: 25.000 € PI: Benedicto Crespo Facorro Research Team: Idalino Rocha González, Nathalia Garrido Torres Nº of researchers: 9 Start/end dates: 01/09/2021 – 30/06/2022

Suicide Prevention and Intervention (SURVIVE): cohort study and nested controlled clinical trials of secondary prevention programs for suicide attempts

Call / Funding body: Call for Strategic Health Actions 2019 / Institute of Health Carlos III Grant ID code: PI19/000685 Awarded Budget 64.130 € PI: Miguel Ruiz Veguilla Research Team: Pablo Reguera Pozuelo, Melisa Valeria Fernández Iturri, Lucía Garrido Sánchez, Cristina García Bernal, Elena García-Ligero Rincón, Nathalia Garrido Torres, Álvaro López Díaz, Ana Vilchez, Cándido González, Maribel Rico, Angelica Clemente Start/end dates: 01/01/2021 – 31/12/2022

The role of ADAMTS2 in schizophrenia: New mechanistic insights into brain functioning and therapeutic perspectives based on mouse and cellular models (RASch)

Call / Funding body: R&D&I Projects – Research Challenges 2019 / Spain State Research Agency Grant ID code: PID2019-109405R Awarded Budget: 108.900 € PI: Benedicto Crespo Facorro Research Team: Álvaro López Díaz, Susana García Cerro, Noelia Rodríguez Pérez, Celia Martín Cuevas, Juan Francisco López Gimenez, Ana Carmen Sánchez Hidalgo, Víctor Darío Ramos Herrero Start/end dates: 01/01/2020 – 31/12/2022

Glutamine Metabolism in the Brain Liver axis in NAFLD (UMBRELLA)

Call / Funding body: Grants to Scientific Research Teams 2019 / BBVA Foundation Grant ID code: Awarded Budget: 125.000 € PI: María Luz Martínez-Chantar (CIC bioGUNE) Research Team: Benedicto Crespo Facorro, Miguel Ruiz Veguilla Start/end dates: 01/01/2020 – 31/12/2022

Enhancing Psychiatric Genetic Counselling, Testing, and Training in Europe (EnGagE)

Call / Funding body: COST (European Cooperation in Science and Technology) Grant ID code: CA17130 Awarded Budget: 0 € PI & afilation: Franziska Degenhardt. University Hospital Essen, Germany. Research Team: Benedicto Crespo Facorro Start/end dates: 17/09/2018 – 16/09/2022

Improving support for people affected by psychological disorders during their training path (PSYCH UP)

Call / Funding body: Erasmus+ programme of the European Union. Grant ID code: 2018-1-FR01-KA202-047959 Awarded Budget: 236.090 € PI & afilation: Benedicto Crespo Facorro. Fundación IDIVAL Start/end dates: 15/09/2018 – 31/08/2021

Mapping Heterogeneity of Neuroanatomical Imaging Signatures of Psychosis via Pattern Analysis (PHENOM)

Call / Funding body: National Institute of Mental Health (NIMH) Grant ID code: R01MH112070 Awarded Budget: 616.842 $ PI & afilation: Davatzikos, Christos / University of Pennsylvania, Philadelphia, PA, United States Research Team: Benedicto Crespo Facorro Start/end dates: 19/09/2017 – 30/06/2021

Technologies and Photonic Devices for Healthy Aging

Convocatoria / Entidad financiadora: State Program for R&D&I Oriented to Society’s Challenges / Spain State Research Agency – FEDER – Ministry of Science, Innovation and Universities Código de expediente: RTC-2017- 6321-1 Presupuesto concedido: 2.800.000 € IP y filiación: Jose Miguel Lopez Higuera, University of Cantabria Equipo investigador: Benedicto Crespo Facorro Fecha de comienzo-fin: 16/06/2018 – 31/12/2021

Atmospheric Electricity Network: coupling with the Earth System, climate and biological systems (ELECTRONET)

Call / Funding body: EU H2020 (UNIÓN EUROPEA) 2017 Identification code: CA15211 Awarded Budget 0 € PI & affilation: prof Konstantinos Kourtidis, Athena – Research & Innovation Center in Information, Communication & Knowledge Technologies, Greece. Research Team: Benedicto Crespo Facorro Start/end dates: 02/01/2017 – 30/12/2020

Translating neuroimaging findings from research into clinical practice (PSYSCAN)

Call / Funding body: European Commission, FP7-HEALTH-2013-INNOVATION-1 Grant ID code: HEALTH.2013.2.2.1-2. Grant agreement no. 603196 Awarded Budget: 8.336.818,54 € PI & affilation: Philip McGuire, King’s College London Research Team: Benedicto Crespo Facorro Start/end dates: 01/02/2014- 31/01/2020

Stratified treatment in schizophrenia: Integrating human and cellular transcriptome results into antipsychotic treatment strategies.

Call / Funding body: Ministry of Economic Affairs and Digital Transformation (MINECO) Grant ID code: SAF2016-76046-R Awarded Budget 181.500 € PI: Benedicto Crespo Facorro Start/end dates: 30/12/2016 – 29/12/2019

Psychiatric Ratings using Intermediate Stratified Markers: providing quantitative biological measures to facilitate de discovery and development of new treatments for social and cognitive deficits in AD, SZ and MD (PRISM)

Call / Funding body: Innovative Medicines Initiative 2 Joint Undertaking. European Union’s Horizon 2020 program Grant ID code: H2020-JTI-IMI2-2015-03 Awarded Budget: 648.000 € PI & affiliation: Celso Arango López, Hospital General Universitario Gregorio Marañón, Madrid Start/end dates: 01/04/2016 -31/02/2019

Personalized medicine in HCV infection: understanding and predicting hepatic and systemic responses in the era of the new antiviral drugs

Call / Funding body: Institute of Health Carlos III Grant ID code: PIE15/00079 Awarded Budget: 638.000 € Start/end dates: 01/01/2016 – 01/01/2019

Valdecilla European research promotion initiative (VALER H2020)

Call / Funding body: Ministry of Economic Affairs and Digital Transformation (MINECO) Grant ID code: ECT-2017-0371 Awarded Budget: 132.642 € Start/end dates: 01/01/2017 – 31/12/2018

Technological solution for relapse prevention and schizophrenia rehabilitation

Call / Funding body: Marqués de Valdecilla Research Institute (IDIVAL) Grant ID code: INNVAL16/03 Awarded Budget: 15.000 € Start/end dates: 02/01/2017 – 29/12/2017

HHRR 

Contract PFIS for Predoctoral training  in health research FI23_00221

Call: Strategic Action in Health 2023 Researcher:  Cristina Morente Montilla Funding body: Institute of Health Carlos III Start/End dates:01/02/2024 – 31/12/2027

Río Hortega researcher CM23_00263

Call: Strategic Action in Health 2023 Researcher:  Manuel Alejandro Muñoz Caracuel Funding body: Institute of Health Carlos III Start/End dates: 01/01/2024 -31/12/2025

Juan Rodés JR22_00075

Call: Strategic Action in Health 2022 Researcher: Nathalia Garrido Torres Funding body: Institute of Health Carlos III Start/End dates: 01/01/2023 – 31/12/2026

Sara Borrell CD22_00153

Title: interaction between the use of antipsychotics and cardiometabolic risk outcomes Call: Strategic Action in Health 2022 Researcher: Almudena Carneiro Barrera Funding body: Institute of Health Carlos III Start/End dates: 01/01/2023 – 31/12/2025

Juan de la Cierva – Formación – FJC2021-047538-I

Call:  Ayuda Juan de la Cierva-Formación 2021 Investigador contratado: María Alemany Navarro Funding body: Spanish State Research Agency (AEI)​​ Start/End dates: 01/01/2023 -31/12/2024

Miguel Servet posdoctoral fellowship – CP21-00106

Call: Acción Strategic Action in Health 2021 Researcher: Diego García González Funding body: Institute of Health Carlos III Start/End dates: 01/01/2022 -31/12/2027

Predoctoral researcher_02201

Call: Grants for predoctoral research training 2021 Researcher: Ana Gómez Garrido Funding body: Regional Government of Andalusia Start/End dates: 01/02/2022 – 01/02/2024

Postdoctoral reseacher – RH-0063

Call: Postdoctoral fellowship for joining SSPA centers Researcher: Ana Sánchez Hidalgo Funding body: Regional Government of Andalusia Start/End dates: 01/06/2022 -01/06/2024

Río Hortega researcher CM20_00015

Call: Strategic Action in Health 2020 Researcher: Nathalia Garrido Torres Funding body: Institute of Health Carlos III Start/End dates: 01/01/2021 -31/12/2022

Postdoctoral researcher RH-0081-2020

Title: Suicide risk prevention in the COVID-19 post-pandemic era : Integrating personalized and biological clinical models Call: Postdoctoral fellowship for joining SSPA centers Researcher: Manuel Canal Rivero Funding body: Regional Government of Andalusia Start/End dates: 01/01/2021 -31/12/2023

Sara Borrell researcher CD19_00183

Title: Searching for cellular, molecular and neurophysiological evidence for the stratified treatment of schizophrenia Call: Strategic Action in Health 2019. Researcher: Susana García Cerro Funding body: Institute of Health Carlos III Start/End dates: 15/01/2020 -14/01/2023